With Osmosis Jones, the Farrelly Brothers venture into animation. A film about talking germs must be a first imagine a combination of Toy Story (1995) and Fantastic Voyage (1966). Naturally, something involving so many bodily fluids and excrescences and has a central character who is a born slob is material perfectly suited to the Farrelly Brothers sensibilities. However, Osmosis Jones has been pitched as a family friendly film and, as a result, all the bodily functions derived humour is relatively restrained as a Farrelly Brothers film goes the film travels fairly much all over the interior of Franks body, for example, but never goes anywhere more explicit than a visit to the colon and the bladder.
In the live-action scenes, Bill Murray and Chris Elliott, seasoned performers at this type of material, go through all the paces, although they and the Farrellys never particularly stretch themselves. That said, the bulk of the film is less the live-action scenes than the animation. The fun to be had in the film is watching it anthropomorphise the inner workings of the human body white blood cells are a police force patrolling the body to fight off infection; the brain is seen as city hall (being a slobs body, it is naturally run by a corrupt mayor); nerve cells are like giant electrical pylons and the bloodstream a multi-lane freeway; the armpits are saunas run by Mafioso germs; the digestive tract is like an international airport with boards announcing the arrival of various items of food; the sinuses are giant dams; and the subconscious is a place where germs can go to watch Franks dreams play on cinema screens. There is considerable ingenuity to seeing what twist the script offers with each new area visited.
One of the great debates in psychology is how much of human behaviour is a product of biochemistry and to what extent behaviour belongs to notions such as free will and choice. Osmosis Jones would seem to offer the unique view that human behaviour is dictated entirely by cells and germs. Germs and cells, it seems, can make the choice over dietary habits and whether the body lets loose a fart; they can even take control of the will and direct the individual to say things and feel twinges of conscience.
The Farrelly Brothers have gone onto make other films such as Me, Myself & Irene (2000), Stuck on You (2004), Fever Pitch (2005), The Heartbreak Kid (2007), Hall Pass (2011) and The Three Stooges (2012). Their other ventures into genre material include:- the stalker black comedy Theres Something About Mary (1998) and Shallow Hal (2001) wherein a man is hypnotised and starts to see ugly girls as beautiful. On his own, Peter Farrelly produced and directed several segments of the comedy anthology Movie 43 (2013).